Thymoides Martius and Schauer, which are frequently used in folk medicine for the treatment of microbial diseases. The genus Lippia has a great number of medicinal species, such as L. The traditional knowledge on the therapeutic potential of plants has been attracting scientific interest seeking new ways to control and treat many diseases caused by microorganisms. Therefore, there is a growing need for novel drugs against bacterial, fungal, and viral infections. The development and spread of antimicrobial resistance is a worldwide concern, due to the negative impacts on public health. Origanoides may be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs. The results obtained in this study indicate that L. Origanoides crude extracts improved the activity in spectrum and intensity. Origanoides leaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts this activity was also confirmed by the MIC evaluation. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases.
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